CASK-AS1

Across TCGA pan-cancer cohorts, CASK-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated CASK-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CASK-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated CASK-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCS show a favorable association.

HNSC, STAD, and KIRC are the cancer types where CASK-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.467	0.272	.001	67	view →
STAD	DFS	Tertile	III,IV	0.465	0.715	<.001	61	view →
KIRC	OS	Tertile	All	0.530	0.715	<.001	53	view →
DLBC	DFS	Tertile	All	0.544	0.907	.002	35	view →
UCS	DFS	Median	IV	0.952	0.367	.001	32	view →
UCEC	DFS	Tertile	All	0.441	0.712	.023	30	view →
ACC	DFS	Quartile	All	0.282	0.694	.007	24	view →
BRCA	DFS	Median	III,IV	0.862	0.724	.001	22	view →
LAML	DFS	Quartile	All	0.622	0.230	.006	18	view →
LIHC	DFS	Tertile	All	0.453	0.606	.009	16	view →
UVM	DFS	Quartile	III,IV	0.184	0.733	.013	15	view →
SKCM	OS	Median	III,IV	0.522	0.265	.001	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

CASK-AS1–HNSC (OS)

Open the HNSC breakdown →