CASK-AS1

Across TCGA pan-cancer cohorts, CASK-AS1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of CASK-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where CASK-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CASK-AS1 is over-expressed in tumor, although a few such as UCEC show the opposite, repressed pattern.

BLCA, HNSC, and LUAD are the cancer types where CASK-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CASK-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	All	+0.325	.002	8	view →
HNSC	Male	All	+0.224	<.001	8	view →
LUAD	Female	II,III,IV	+0.341	<.001	7	view →
STAD	All	All	+0.307	.001	7	view →
ESCA	All	All	+0.663	.001	5	view →
LUSC	All	All	+0.285	<.001	5	view →
KIRC	All	All	+0.126	<.001	5	view →
BRCA	All	II,III,IV	+0.203	<.001	4	view →
COAD	All	All	+0.183	.007	4	view →
READ	Female	All	+0.394	.028	2	view →
UCEC	All	IV	−0.339	.003	2	view →
KIRP	All	IV	+0.300	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

CASK-AS1–BLCA

Open the BLCA breakdown →