CASD1

Across TCGA cell cohorts, CASD1 mutation is significantly associated with the RNA expression of many other genes, with 149 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CASD1-associated genes across cancer lineages are OR4E2, CSPG5, and TCTN3. Each is linked with CASD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CASD1-to-partner and partner-to-CASD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4E2 grouped by CASD1-low versus CASD1-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASD1→partner) and Y-score (partner→CASD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	OR4E2 →	+0.016	+5.614	<.001	.002	3	1
LARGE_INTESTINE	CSPG5 →	+0.724	+2.451	.001	.009	3	1
LARGE_INTESTINE	TCTN3 →	+0.642	+3.502	<.001	.001	3	1
LARGE_INTESTINE	MAGEB4 →	+0.008	+2.830	.001	.004	3	1
LARGE_INTESTINE	STIL →	+0.652	+3.234	.001	.004	3	1
LARGE_INTESTINE	PPAN →	+0.547	+3.067	.008	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 149 associations by consensus.

OR4E2 by CASD1 expression — PANCREAS

Explore this box plot interactively →