CASC3

Across TCGA patient cohorts, CASC3 RNA expression is significantly associated with the protein abundance of many other proteins, with 19,427 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CASC3-associated proteins across cancer lineages are SMC3, NXF1, and VEZF1. Each is linked with CASC3 in more than 6 cancer types. Because this analysis shows association rather than direction, both CASC3-to-partner and partner-to-CASC3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CASC3 versus SMC3 in LSCC, with a Pearson correlation of 0.56.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CASC3→partner) and Y-score (partner→CASC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SMC3 →	+0.240	+0.443	<.001	<.001	3	7
LSCC	NXF1 →	+0.260	+0.588	<.001	<.001	3	6
LSCC	VEZF1 →	+0.435	+0.584	<.001	<.001	3	6
GBM	WDR5 →	+0.281	+0.370	<.001	<.001	3	6
LSCC	SF3A3 →	+0.186	+0.435	<.001	<.001	3	6
GBM	SMC1A →	+0.312	+0.368	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,427 associations by consensus.

CASC3 vs SMC3 — LSCC

Explore this scatter interactively →