CASC3

Across TCGA patient cohorts, CASC3 mutation is significantly associated with the RNA expression of many other genes, with 2,624 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CASC3-associated genes across cancer lineages are MIR4477A, RNU6-1309P, and DCP1A. Each is linked with CASC3 in more than 2 cancer types. Because this analysis shows association rather than direction, both CASC3-to-partner and partner-to-CASC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4477A grouped by CASC3-low versus CASC3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASC3→partner) and Y-score (partner→CASC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR4477A →	+0.867	+3.637	<.001	<.001	3	3
LUAD	RNU6-1309P →	+0.702	+3.202	<.001	.006	3	2
UCEC	DCP1A →	+0.421	+3.364	.007	.004	3	2
UCEC	RNA5SP414 →	+0.383	+2.085	.001	.001	3	2
UCEC	FRG1HP →	+0.529	+3.721	<.001	<.001	3	2
UCEC	RNA5SP411 →	+0.919	+1.946	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,624 associations by consensus.

MIR4477A by CASC3 expression — SKCM

Explore this box plot interactively →