CASC3

Across TCGA cell cohorts, CASC3 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CASC3-associated genes across cancer lineages are SLC15A5, IFNA7, and RLN1. Each is linked with CASC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CASC3-to-partner and partner-to-CASC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC15A5 grouped by CASC3-low versus CASC3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASC3→partner) and Y-score (partner→CASC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SLC15A5 →	+0.029	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	IFNA7 →	+0.035	+5.643	<.001	.002	3	1
BLOOD_Leukemia	RLN1 →	+0.507	+3.781	<.001	.002	3	1
BLOOD_Leukemia	LRCH2 →	+0.581	+3.129	<.001	.005	3	1
BLOOD_Leukemia	OR11H1 →	+0.058	+3.786	<.001	.002	3	1
BLOOD_Leukemia	GC →	+0.097	+3.106	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

SLC15A5 by CASC3 expression — BLOOD_Lymphoma

Explore this box plot interactively →