CARS1

Across TCGA pan-cancer cohorts, CARS1 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated CARS1 data layer compared with 24 for mass-spec protein and 8 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher CARS1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CARS1 expression acts as an unfavorable survival marker, although some lineages such as STAD and SKCM show a favorable association.

THYM, HNSC, and ACC are the cancer types where CARS1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
HNSC	DFS	Median	All	0.130	0.696	.001	36	view →
ACC	OS	Median	All	0.188	0.820	<.001	12	view →
SARC	OS	Median	All	0.241	0.766	.022	6	view →
PRAD	DFS	Median	All	0.139	0.888	<.001	6	view →
STAD	OS	Median	IV	1.000	0.271	.014	6	view →
SKCM	DFS	Median	II,III,IV	0.733	0.215	.020	4	view →
UCEC	DFS	Median	All	0.896	0.620	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

CARS1–THYM (OS)

Open the THYM breakdown →