CARS1

Across TCGA pan-cancer cohorts, CARS1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of CARS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CARS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CARS1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

KIRC, HNSC, and COAD are the cancer types where CARS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CARS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.009	<.001	12	view →
HNSC	Male	All	+0.686	<.001	11	view →
COAD	Male	II,III,IV	+0.644	<.001	10	view →
LUAD	Male	II,III,IV	+0.609	<.001	9	view →
STAD	Male	II,III,IV	+0.870	<.001	8	view →
KIRP	All	All	+0.448	<.001	7	view →
LIHC	Male	All	+0.575	<.001	6	view →
UCEC	All	All	+0.434	.018	6	view →
BRCA	All	All	+0.331	<.001	6	view →
CHOL	All	All	+1.358	<.001	5	view →
LUSC	Male	All	+0.622	<.001	5	view →
THCA	Male	III,IV	−0.374	.017	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

CARS1–KIRC

Open the KIRC breakdown →