CARS1

Across TCGA pan-cancer cohorts, CARS1 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated CARS1 data layer compared with 24 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher CARS1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CARS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

CCRCC, HNSC, and LSCC are the cancer types where CARS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.888	1.000	.003	24	view →
HNSC	DFS	Median	IV	0.827	0.562	.017	20	view →
LSCC	DFS	Quartile	III,IV	0.457	1.000	.006	18	view →
LUAD	OS	Quartile	III,IV	0.772	1.000	.020	8	view →
PDAC	DFS	Tertile	II,III,IV	0.646	0.425	.037	6	view →
OV	DFS	Median	All	1.000	0.857	.029	4	view →
GBM	DFS	Median	All	0.277	0.449	.019	2	view →
UCEC	DFS	Median	II,III,IV	0.826	1.000	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

CARS1–CCRCC (OS)

Open the CCRCC breakdown →