CARS1

Across TCGA patient cohorts, CARS1 RNA expression is significantly associated with the mutation status of many other genes, with 10,085 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CARS1-associated genes across cancer lineages are TP53, RNF213, and DYNC2H1. Each is linked with CARS1 in more than 6 cancer types. Because this analysis shows association rather than direction, both CARS1-to-partner and partner-to-CARS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TP53 grouped by CARS1-low versus CARS1-high in SKCM.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CARS1→partner) and Y-score (partner→CARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TP53 →	+3.832	+0.419	<.001	<.001	3	7
CESC	RNF213 →	+3.214	+0.373	.008	.003	3	6
UCEC	DYNC2H1 →	+1.283	+0.362	<.001	<.001	3	6
LUAD	DNAH11 →	+2.205	+0.356	<.001	<.001	3	5
STAD	TTN →	+0.905	+0.217	<.001	<.001	2	6
LGG	NF1 →	+3.482	+0.437	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,085 associations by consensus.

TP53 by CARS1 expression — SKCM

Explore this box plot interactively →