CARS1

Across TCGA patient cohorts, CARS1 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CARS1-associated genes across cancer lineages are ERK2, 4E-BP1, and MSH2. Each is linked with CARS1 in more than 3 cancer types. Because this analysis shows association rather than direction, both CARS1-to-partner and partner-to-CARS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by CARS1-low versus CARS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CARS1→partner) and Y-score (partner→CARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.187	+2.321	.001	.005	3	3
SKCM	4E-BP1 →	+0.382	+3.000	.028	.036	2	4
UCEC	MSH2 →	-0.237	-2.312	<.001	<.001	3	2
UCEC	Notch1 →	+0.171	+3.013	<.001	<.001	3	2
UCEC	p27_pT198 →	+0.097	+1.643	.003	.003	3	2
UCEC	PCNA →	+0.172	+1.201	.010	.028	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

ERK2 by CARS1 expression — UCEC

Explore this box plot interactively →