CARS1

Across TCGA cell cohorts, CARS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,217 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CARS1-associated GO terms across cancer lineages are Smooth muscle cell migration, Formate biosynthetic process, and Negative regulation of translation in response to endoplasmic reticulum stress. Each is linked with CARS1 in more than 9 cancer types. Because this analysis shows association rather than direction, both CARS1-to-partner and partner-to-CARS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Smooth muscle cell migration grouped by CARS1-low versus CARS1-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CARS1→partner) and Y-score (partner→CARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Smooth muscle cell migration →	+0.232	+0.858	<.001	.001	3	10
STOMACH	Formate biosynthetic process →	+0.128	+0.965	.002	.001	3	10
BONE	Negative regulation of translation in response to endoplasmic reticulum stress →	+0.182	+1.216	<.001	<.001	3	10
BONE	Golgi vesicle transport →	+0.052	+0.856	<.001	.006	3	10
BLOOD_Myeloma	Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress →	+0.184	+1.316	<.001	<.001	3	9
STOMACH	L-glutamate biosynthetic process →	+0.193	+1.059	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,217 associations by consensus.

Smooth muscle cell migration by CARS1 expression — BLOOD_Myeloma

Explore this box plot interactively →