CARS1-AS1

Across TCGA pan-cancer cohorts, CARS1-AS1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated CARS1-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CARS1-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated CARS1-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and THCA are the cancer types where CARS1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	IV	0.503	0.328	.001	72	view →
SKCM	OS	Tertile	III,IV	0.598	0.348	.001	49	view →
THCA	OS	Quartile	All	0.827	0.988	.004	34	view →
COAD	DFS	Quartile	III,IV	0.405	0.691	.004	25	view →
LUAD	OS	Median	III,IV	0.823	0.482	<.001	24	view →
OV	DFS	Tertile	IV	0.307	0.586	.010	24	view →
PAAD	DFS	Tertile	All	0.264	0.430	.010	19	view →
UCS	DFS	Median	IV	0.909	0.416	.008	18	view →
STAD	DFS	Median	IV	0.204	0.646	.014	17	view →
KIRC	DFS	Median	All	0.568	0.674	.002	17	view →
KIRP	DFS	Median	II,III,IV	0.305	0.653	.027	16	view →
KICH	OS	Tertile	All	0.695	1.000	.022	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

CARS1-AS1–HNSC (OS)

Open the HNSC breakdown →