CARS1-AS1

Across TCGA pan-cancer cohorts, CARS1-AS1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of CARS1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CARS1-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CARS1-AS1 is over-expressed in tumor.

COAD, KIRC, and KIRP are the cancer types where CARS1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CARS1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+0.142	<.001	9	view →
KIRC	All	All	+0.020	<.001	5	view →
KIRP	Male	II,III,IV	+0.016	.006	4	view →
KICH	All	II,III,IV	+0.060	.029	3	view →
UCEC	All	III,IV	+0.096	.038	2	view →
STAD	Male	II,III,IV	+0.092	.020	2	view →
CHOL	All	II,III,IV	+0.075	.004	2	view →
HNSC	Male	II,III,IV	+0.015	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

CARS1-AS1–COAD

Open the COAD breakdown →