CARMIL1

Across TCGA patient cohorts, CARMIL1 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CARMIL1-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and IGFBP2. Each is linked with CARMIL1 in more than 3 cancer types. Because this analysis shows association rather than direction, both CARMIL1-to-partner and partner-to-CARMIL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CARMIL1-low versus CARMIL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CARMIL1→partner) and Y-score (partner→CARMIL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.681	-2.321	<.001	<.001	3	3
LUSC	Caspase-7-cleavedD198 →	+0.632	+2.816	.021	.036	1	4
UCEC	IGFBP2 →	-0.615	-1.678	.001	.019	3	2
UCEC	JNK_pT183_Y185 →	-0.160	-1.584	.001	.017	3	2
UCEC	Ku80 →	+0.230	+1.598	.001	.001	3	2
UCEC	MSH2 →	-0.214	-2.476	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

ATM by CARMIL1 expression — UCEC

Explore this box plot interactively →