CARMIL1

Across TCGA pan-cancer cohorts, CARMIL1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of CARMIL1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CARMIL1 RNA is repressed in tumor relative to normal tissue. In most cancer types CARMIL1 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and HNSC are the cancer types where CARMIL1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CARMIL1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	III,IV	−1.212	<.001	12	view →
KICH	Female	III,IV	−2.886	<.001	11	view →
HNSC	All	III,IV	+1.048	<.001	11	view →
STAD	All	III,IV	+1.721	<.001	10	view →
LUAD	Female	All	−0.609	<.001	7	view →
LIHC	All	All	+0.643	<.001	6	view →
BRCA	All	II,III,IV	+0.524	<.001	6	view →
CHOL	Male	All	+2.753	<.001	5	view →
THCA	All	All	−0.315	.002	5	view →
ESCA	All	All	+1.317	.017	4	view →
BLCA	Male	III,IV	+0.924	.002	4	view →
COAD	Female	All	−0.537	.011	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

CARMIL1–KIRC

Open the KIRC breakdown →