CARMIL1

Across TCGA cell cohorts, CARMIL1 mutation is significantly associated with the RNA expression of many other genes, with 755 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CARMIL1-associated genes across cancer lineages are OR1L3, RNF8, and SRF. Each is linked with CARMIL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CARMIL1-to-partner and partner-to-CARMIL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L3 grouped by CARMIL1-low versus CARMIL1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CARMIL1→partner) and Y-score (partner→CARMIL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR1L3 →	+0.014	+4.415	.001	.007	3	2
BLOOD_Leukemia	RNF8 →	+0.551	+3.199	.002	.007	3	2
BLOOD_Leukemia	SRF →	+0.442	+3.199	.003	.007	3	2
BLOOD_Leukemia	OR11H1 →	+0.030	+2.979	<.001	.007	3	2
BLOOD_Leukemia	LZIC →	+0.568	+3.259	.004	.006	3	2
LARGE_INTESTINE	ATP9B →	+1.074	+3.131	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 755 associations by consensus.

OR1L3 by CARMIL1 expression — SKIN

Explore this box plot interactively →