CARF

Across TCGA patient cohorts, CARF mutation is significantly associated with the RNA expression of many other genes, with 2,526 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CARF-associated genes across cancer lineages are CRIP1P1, RNA5SP519, and AQP7P5. Each is linked with CARF in more than 2 cancer types. Because this analysis shows association rather than direction, both CARF-to-partner and partner-to-CARF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRIP1P1 grouped by CARF-low versus CARF-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CARF→partner) and Y-score (partner→CARF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CRIP1P1 →	+0.234	+5.268	<.001	.003	3	3
BLCA	RNA5SP519 →	+0.159	+2.744	<.001	.004	3	3
LIHC	AQP7P5 →	+0.060	+5.289	.002	.001	3	2
CESC	RPA3P2 →	+0.106	+4.127	<.001	.003	3	2
CESC	RN7SKP68 →	+0.248	+4.918	.008	<.001	3	2
BLCA	FXNP1 →	+0.028	+3.825	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,526 associations by consensus.

CRIP1P1 by CARF expression — BRCA

Explore this box plot interactively →