CARF

Across TCGA cell cohorts, CARF mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CARF-associated genes across cancer lineages are OR1E1, SH3GL2, and GHR. Each is linked with CARF in more than 1 cancer types. Because this analysis shows association rather than direction, both CARF-to-partner and partner-to-CARF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1E1 grouped by CARF-low versus CARF-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CARF→partner) and Y-score (partner→CARF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR1E1 →	+0.152	+4.662	<.001	.005	3	1
LARGE_INTESTINE	SH3GL2 →	+1.177	+3.474	.001	.003	3	1
LARGE_INTESTINE	GHR →	+0.494	+3.667	.001	.003	3	1
LARGE_INTESTINE	PCCB →	+0.707	+3.125	<.001	.008	3	1
LARGE_INTESTINE	GNMT →	+0.254	+3.302	<.001	.008	3	1
LARGE_INTESTINE	EAPP →	+0.539	+3.087	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

OR1E1 by CARF expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →