CARD17

Across TCGA cell cohorts, CARD17 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CARD17-associated genes across cancer lineages are OR4D5, PNLIP, and SPATA31D4. Each is linked with CARD17 in more than 1 cancer types. Because this analysis shows association rather than direction, both CARD17-to-partner and partner-to-CARD17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4D5 grouped by CARD17-low versus CARD17-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CARD17→partner) and Y-score (partner→CARD17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR4D5 →	+0.014	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	PNLIP →	+0.005	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	SPATA31D4 →	+0.005	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	SPINK14 →	+0.267	+4.662	<.001	.005	3	1
SKIN	LY6H →	+0.175	+4.095	<.001	.009	3	1
SKIN	KRTAP9-8 →	+0.043	+4.467	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

OR4D5 by CARD17 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →