CARD10

Across TCGA pan-cancer cohorts, CARD10 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CARD10 data layer compared with 23 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CARD10 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CARD10 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, LSCC, and PDAC are the cancer types where CARD10 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	1.000	0.565	.001	31	view →
LSCC	OS	Median	II,III,IV	0.771	0.927	.009	13	view →
PDAC	DFS	Median	All	0.860	0.507	.013	3	view →
LUAD	OS	Median	III,IV	0.896	0.310	.032	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CARD10–HNSC (DFS)

Open the HNSC breakdown →