CARD10

Across TCGA cell cohorts, CARD10 mutation is significantly associated with the RNA expression of many other genes, with 683 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CARD10-associated genes across cancer lineages are C12orf40, TNRC6B, and FBXL4. Each is linked with CARD10 in more than 1 cancer types. Because this analysis shows association rather than direction, both CARD10-to-partner and partner-to-CARD10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C12orf40 grouped by CARD10-low versus CARD10-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CARD10→partner) and Y-score (partner→CARD10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	C12orf40 →	+0.008	+3.444	<.001	.003	3	2
LARGE_INTESTINE	TNRC6B →	+0.764	+3.064	<.001	.009	3	2
LARGE_INTESTINE	FBXL4 →	+0.643	+3.169	<.001	.006	3	2
LARGE_INTESTINE	OSCP1 →	+0.716	+3.502	.002	.001	3	2
LARGE_INTESTINE	ID3 →	+1.987	+2.451	.004	.009	3	2
LARGE_INTESTINE	DPH5 →	+0.744	+3.169	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 683 associations by consensus.

C12orf40 by CARD10 expression — OVARY

Explore this box plot interactively →