CAPZB

Across TCGA patient cohorts, CAPZB mutation is significantly associated with the RNA expression of many other genes, with 423 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAPZB-associated genes across cancer lineages are NPVF, PGAM3P, and AFM. Each is linked with CAPZB in more than 1 cancer types. Because this analysis shows association rather than direction, both CAPZB-to-partner and partner-to-CAPZB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPVF grouped by CAPZB-low versus CAPZB-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPZB→partner) and Y-score (partner→CAPZB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	NPVF →	+0.037	+5.444	<.001	.002	3	2
COAD	PGAM3P →	+0.091	+4.821	.001	.003	3	2
HNSC	AFM →	+0.078	+4.047	.004	.005	3	1
UCEC	LINC01101 →	-0.702	-2.796	.005	.003	3	1
COAD	IL3 →	+0.083	+3.942	.001	.002	3	1
UCEC	TRBV7-9 →	+0.878	+3.467	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 423 associations by consensus.

NPVF by CAPZB expression — BLCA

Explore this box plot interactively →