CAPZB

Across TCGA pan-cancer cohorts, CAPZB RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CAPZB’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CAPZB RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CAPZB is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

KIRC, HNSC, and LIHC are the cancer types where CAPZB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CAPZB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.519	<.001	12	view →
HNSC	Female	II,III,IV	+0.513	<.001	10	view →
LIHC	Female	II,III,IV	+1.001	<.001	9	view →
COAD	All	All	−0.351	<.001	8	view →
THCA	Male	III,IV	−0.338	<.001	8	view →
KICH	Female	II,III,IV	−1.174	<.001	7	view →
STAD	Male	II,III,IV	+0.551	<.001	6	view →
BRCA	All	III,IV	+0.427	<.001	6	view →
CHOL	All	All	+1.215	<.001	5	view →
LUSC	All	All	+0.167	.015	4	view →
READ	Female	All	−0.661	.001	2	view →
UCEC	All	All	−0.256	.041	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CAPZB–KIRC

Open the KIRC breakdown →