CAPZB

Across TCGA patient cohorts, CAPZB mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAPZB-associated genes across cancer lineages are INPP4B, EGFR_pY1068, and JNK_pT183_Y185. Each is linked with CAPZB in more than 1 cancer types. Because this analysis shows association rather than direction, both CAPZB-to-partner and partner-to-CAPZB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by CAPZB-low versus CAPZB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPZB→partner) and Y-score (partner→CAPZB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.328	-3.000	.043	.036	3	2
UCEC	EGFR_pY1068 →	-0.258	-2.321	.040	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.182	-2.308	.031	.036	3	1
UCEC	MSH2 →	-0.371	-2.973	.001	.035	3	1
UCEC	MSH6 →	-0.517	-2.999	.001	.035	3	1
UCEC	VHL →	-1.171	-3.000	<.001	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

INPP4B by CAPZB expression — UCEC

Explore this box plot interactively →