CAPZB

Across TCGA cell cohorts, CAPZB mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CAPZB-associated genes across cancer lineages are ITGAD, FCN2, and PRAMEF20. Each is linked with CAPZB in more than 1 cancer types. Because this analysis shows association rather than direction, both CAPZB-to-partner and partner-to-CAPZB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITGAD grouped by CAPZB-low versus CAPZB-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPZB→partner) and Y-score (partner→CAPZB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ITGAD →	+0.009	+2.925	.003	.007	3	1
LARGE_INTESTINE	FCN2 →	+0.028	+4.000	<.001	<.001	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	GSG1L2 →	+0.011	+3.700	<.001	.009	3	1
LARGE_INTESTINE	TEX46 →	+0.175	+3.497	<.001	.004	3	1
LARGE_INTESTINE	TBR1 →	+0.040	+3.333	<.001	.009	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

ITGAD by CAPZB expression — LARGE_INTESTINE

Explore this box plot interactively →