CAPZA1

Across TCGA patient cohorts, CAPZA1 mutation is significantly associated with the RNA expression of many other genes, with 2,350 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAPZA1-associated genes across cancer lineages are MIR6765, RPL35AP3, and RNU6-628P. Each is linked with CAPZA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAPZA1-to-partner and partner-to-CAPZA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6765 grouped by CAPZA1-low versus CAPZA1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPZA1→partner) and Y-score (partner→CAPZA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR6765 →	+0.297	+3.786	<.001	.003	3	2
LIHC	RPL35AP3 →	+0.233	+5.758	<.001	.003	3	2
UCEC	RNU6-628P →	+0.333	+1.789	<.001	.009	3	2
UCEC	RPL31P47 →	+0.347	+2.577	<.001	<.001	3	2
UCEC	CISD3 →	+0.528	+2.662	.002	<.001	3	1
UCEC	RDM1 →	+0.491	+2.169	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,350 associations by consensus.

MIR6765 by CAPZA1 expression — CESC

Explore this box plot interactively →