CAPSL

Across TCGA patient cohorts, CAPSL mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAPSL-associated genes across cancer lineages are ASNS, STAT3_pY705, and Chk2. Each is linked with CAPSL in more than 2 cancer types. Because this analysis shows association rather than direction, both CAPSL-to-partner and partner-to-CAPSL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by CAPSL-low versus CAPSL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPSL→partner) and Y-score (partner→CAPSL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.424	+3.000	.015	.036	3	3
UCEC	STAT3_pY705 →	-0.564	-3.321	<.001	.009	3	2
SKCM	Chk2 →	+0.226	+2.700	.024	.006	3	2
UCEC	EGFR_pY1068 →	-0.351	-3.169	.003	.019	3	1
UCEC	Gab2 →	+0.540	+3.169	.001	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.248	-3.169	.002	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

ASNS by CAPSL expression — UCEC

Explore this box plot interactively →