CAPSL

Across TCGA pan-cancer cohorts, CAPSL RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of CAPSL’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where CAPSL RNA is repressed in tumor relative to normal tissue. In most cancer types CAPSL is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and THCA are the cancer types where CAPSL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CAPSL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−1.700	<.001	11	view →
KIRC	Male	IV	−1.335	<.001	11	view →
THCA	Male	III,IV	−2.768	<.001	9	view →
LUAD	All	III,IV	−2.406	<.001	9	view →
LUSC	Female	All	−2.958	<.001	8	view →
LIHC	All	II,III,IV	+0.057	<.001	7	view →
BRCA	All	III,IV	+1.601	<.001	6	view →
CHOL	Female	All	+0.080	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

CAPSL–KICH

Open the KICH breakdown →