CAPS2

Across TCGA patient cohorts, CAPS2 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAPS2-associated genes across cancer lineages are PCNA, c-Kit, and A-Raf_pS299. Each is linked with CAPS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAPS2-to-partner and partner-to-CAPS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by CAPS2-low versus CAPS2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPS2→partner) and Y-score (partner→CAPS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.353	+3.012	.003	.018	3	2
COAD	c-Kit →	-0.962	-3.169	.001	.018	3	2
UCEC	A-Raf_pS299 →	-0.101	-1.906	.006	.015	3	2
UCEC	Notch1 →	+0.158	+2.179	<.001	.001	3	2
UCEC	Akt_pT308 →	+0.419	+1.201	.032	.028	3	2
UCEC	PDCD4 →	-0.466	-1.916	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

PCNA by CAPS2 expression — COAD

Explore this box plot interactively →