CAPS2

Across TCGA pan-cancer cohorts, CAPS2 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated CAPS2 data layer compared with 5 for mutation status.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher CAPS2 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated CAPS2 expression acts as an unfavorable survival marker, although some lineages such as UCS and BRCA show a favorable association.

UCS, BRCA, and UVM are the cancer types where CAPS2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Median	All	0.603	0.252	<.001	86	view →
BRCA	OS	Median	III,IV	0.909	0.751	<.001	46	view →
UVM	DFS	Quartile	III,IV	0.230	0.813	.010	22	view →
SKCM	OS	Tertile	II,III,IV	0.457	0.265	.007	20	view →
STAD	DFS	Quartile	II,III,IV	0.758	0.366	.025	18	view →
KIRP	DFS	Tertile	All	0.913	0.613	.013	18	view →
HNSC	DFS	Quartile	III,IV	0.556	0.792	.011	17	view →
PAAD	DFS	Tertile	All	0.414	0.178	.026	12	view →
LIHC	DFS	Quartile	All	0.331	0.489	.007	8	view →
COAD	DFS	Median	III,IV	0.514	0.272	.009	8	view →
LUSC	DFS	Quartile	III,IV	0.378	0.709	.020	8	view →
MESO	OS	Quartile	IV	0.915	0.320	.031	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

CAPS2–UCS (DFS)

Open the UCS breakdown →