CAPS2

Across TCGA cell cohorts, CAPS2 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CAPS2-associated genes across cancer lineages are IL2, KRTAP4-11, and GLB1L3. Each is linked with CAPS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAPS2-to-partner and partner-to-CAPS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL2 grouped by CAPS2-low versus CAPS2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPS2→partner) and Y-score (partner→CAPS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IL2 →	+0.040	+4.022	<.001	.006	3	2
CNS	KRTAP4-11 →	+0.746	+4.981	<.001	.008	3	1
LARGE_INTESTINE	GLB1L3 →	+0.986	+3.453	<.001	.009	2	1
LARGE_INTESTINE	CEACAM20 →	+0.194	+4.022	<.001	.001	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

IL2 by CAPS2 expression — LARGE_INTESTINE

Explore this box plot interactively →