CAPS

Across TCGA patient cohorts, CAPS mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAPS-associated genes across cancer lineages are OR6C72P, MIR7155, and MIR3170. Each is linked with CAPS in more than 1 cancer types. Because this analysis shows association rather than direction, both CAPS-to-partner and partner-to-CAPS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6C72P grouped by CAPS-low versus CAPS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPS→partner) and Y-score (partner→CAPS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OR6C72P →	+0.084	+5.027	.002	.004	3	2
UCEC	MIR7155 →	+0.788	+4.694	<.001	.007	3	1
UCEC	MIR3170 →	+1.154	+4.326	<.001	.007	3	1
BLCA	RNU6-797P →	+0.490	+6.147	<.001	.002	3	1
UCEC	LINC00706 →	+0.239	+4.279	<.001	.008	3	1
UCEC	SLC20A1P2 →	+0.080	+5.123	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

OR6C72P by CAPS expression — UCEC

Explore this box plot interactively →