CAPS

Across TCGA pan-cancer cohorts, CAPS RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CAPS’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CAPS RNA is repressed in tumor relative to normal tissue. In most cancer types CAPS is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and KIRP are the cancer types where CAPS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CAPS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−2.343	<.001	12	view →
KICH	Female	All	−2.155	<.001	10	view →
KIRP	Male	All	−1.865	<.001	9	view →
LUSC	Female	II,III,IV	−2.670	<.001	8	view →
LIHC	Female	All	+1.039	<.001	8	view →
LUAD	Female	All	−1.452	<.001	7	view →
BRCA	All	III,IV	+1.523	<.001	6	view →
COAD	All	All	+0.678	.001	6	view →
CHOL	Female	All	+4.316	<.001	3	view →
BLCA	All	IV	+1.852	.046	1	view →
READ	Female	All	+1.148	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CAPS–KIRC

Open the KIRC breakdown →