Across TCGA cell cohorts, CAPN8 mutation is significantly associated with the RNA expression of many other genes, with 100 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CAPN8-associated genes across cancer lineages are TFAP2D, MYF6, and OR4E1. Each is linked with CAPN8 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAPN8-to-partner and partner-to-CAPN8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPN8→partner) and Y-score (partner→CAPN8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TFAP2D →	+0.015	+4.930	.002	.008	3	1
OESOPHAGUS	MYF6 →	+0.013	+4.906	<.001	.006	3	1
OESOPHAGUS	OR4E1 →	+0.016	+4.906	<.001	.006	3	1
LARGE_INTESTINE	SPAG1 →	+0.885	+3.364	.004	.002	3	1
LARGE_INTESTINE	KLHL2 →	+0.689	+3.169	.002	.009	3	1
LARGE_INTESTINE	ARL1 →	+0.518	+3.064	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 100 associations by consensus.

Exploration

CAPN8 survival (RNA) · tumor vs normal (RNA) · all CAPN8 data types