CAPN5

Across TCGA pan-cancer cohorts, CAPN5 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CAPN5 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher CAPN5 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CAPN5 expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

COAD, HNSC, and PDAC are the cancer types where CAPN5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.886	.019	30	view →
HNSC	DFS	Tertile	II,III,IV	0.867	0.986	.003	22	view →
PDAC	OS	Quartile	All	1.000	0.749	.008	10	view →
GBM	OS	Tertile	All	0.256	0.524	.008	10	view →
CCRCC	OS	Tertile	All	1.000	0.886	.014	9	view →
LUAD	OS	Median	All	0.609	0.866	.012	8	view →
LSCC	DFS	Quartile	II,III,IV	0.840	1.000	.015	8	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CAPN5–COAD (DFS)

Open the COAD breakdown →