CAPN3

Across TCGA patient cohorts, CAPN3 mutation is significantly associated with the RNA expression of many other genes, with 4,715 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAPN3-associated genes across cancer lineages are PLCB3, SEC13, and CPAMD8. Each is linked with CAPN3 in more than 2 cancer types. Because this analysis shows association rather than direction, both CAPN3-to-partner and partner-to-CAPN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLCB3 grouped by CAPN3-low versus CAPN3-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPN3→partner) and Y-score (partner→CAPN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	PLCB3 →	+0.858	+3.203	.002	.009	3	3
UCEC	SEC13 →	+0.416	+2.146	<.001	<.001	3	3
UCEC	CPAMD8 →	-1.243	-2.701	<.001	<.001	3	3
UCEC	SFMBT1 →	+0.608	+1.698	<.001	<.001	3	3
UCEC	SLBP →	+0.482	+1.698	<.001	<.001	3	3
UCEC	H2AZ1 →	+0.674	+2.179	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,715 associations by consensus.

PLCB3 by CAPN3 expression — STAD

Explore this box plot interactively →