CAPN3

Across TCGA pan-cancer cohorts, CAPN3 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CAPN3’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where CAPN3 RNA is repressed in tumor relative to normal tissue. In most cancer types CAPN3 is over-expressed in tumor, although a few such as LUAD and KICH show the opposite, repressed pattern.

LUAD, KICH, and HNSC are the cancer types where CAPN3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CAPN3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	−1.276	<.001	11	view →
KICH	All	II,III,IV	−1.420	<.001	8	view →
HNSC	Male	All	−1.313	.001	8	view →
LUSC	Female	All	−1.111	<.001	7	view →
THCA	All	All	+0.537	<.001	7	view →
KIRP	Female	II,III,IV	−1.859	.001	6	view →
BRCA	All	III,IV	−0.954	<.001	6	view →
UCEC	All	II,III,IV	−0.404	<.001	6	view →
KIRC	Male	All	−0.687	<.001	4	view →
COAD	Female	IV	+1.029	.010	1	view →
LIHC	All	All	+0.110	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CAPN3–LUAD

Open the LUAD breakdown →