CAPN3

Across TCGA patient cohorts, CAPN3 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAPN3-associated genes across cancer lineages are S6, TIGAR, and Caspase-7-cleavedD198. Each is linked with CAPN3 in more than 2 cancer types. Because this analysis shows association rather than direction, both CAPN3-to-partner and partner-to-CAPN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S6 grouped by CAPN3-low versus CAPN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPN3→partner) and Y-score (partner→CAPN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	S6 →	+0.186	+2.000	.031	.029	3	3
UCEC	TIGAR →	+0.131	+1.486	.008	.007	3	3
UCEC	Caspase-7-cleavedD198 →	+0.618	+1.604	.001	.010	3	3
UCEC	FoxM1 →	+0.205	+1.716	.014	.003	3	2
UCEC	JNK_pT183_Y185 →	-0.189	-2.247	<.001	.001	3	2
UCEC	mTOR_pS2448 →	-0.123	-1.828	.011	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

S6 by CAPN3 expression — UCEC

Explore this box plot interactively →