CAPN3

Across TCGA cell cohorts, CAPN3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,221 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CAPN3-associated GO terms across cancer lineages are Protein localization to nuclear inner membrane, Sperm motility, and Flagellated sperm motility. Each is linked with CAPN3 in more than 10 cancer types. Because this analysis shows association rather than direction, both CAPN3-to-partner and partner-to-CAPN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to nuclear inner membrane grouped by CAPN3-low versus CAPN3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPN3→partner) and Y-score (partner→CAPN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Protein localization to nuclear inner membrane →	-0.137	-0.889	.006	<.001	3	11
LARGE_INTESTINE	Sperm motility →	-0.083	-0.817	<.001	<.001	3	10
LARGE_INTESTINE	Flagellated sperm motility →	-0.083	-0.817	<.001	<.001	3	10
LARGE_INTESTINE	Cilium movement involved in cell motility →	-0.081	-0.817	<.001	<.001	3	9
URINARY_TRACT	Negative regulation of meiotic nuclear division →	-0.174	-0.841	.003	.006	3	9
KIDNEY	Chiasma assembly →	+0.211	+0.610	.008	.004	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,221 associations by consensus.

Protein localization to nuclear inner membrane by CAPN3 expression — BONE

Explore this box plot interactively →