CAPN3

Across TCGA cell cohorts, CAPN3 mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CAPN3-associated genes across cancer lineages are ARMH2, CCL7, and CST5. Each is linked with CAPN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAPN3-to-partner and partner-to-CAPN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARMH2 grouped by CAPN3-low versus CAPN3-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPN3→partner) and Y-score (partner→CAPN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ARMH2 →	+0.030	+4.906	<.001	.006	3	1
BLOOD_Lymphoma	CCL7 →	+0.084	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	CST5 →	+0.532	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	MROH2B →	+0.116	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	MAGEE2 →	+0.006	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	BSX →	+0.214	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

ARMH2 by CAPN3 expression — OESOPHAGUS

Explore this box plot interactively →