CAPN2

Across TCGA patient cohorts, CAPN2 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAPN2-associated genes across cancer lineages are Ku80, Akt_pS473, and p62 Lck ligand. Each is linked with CAPN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAPN2-to-partner and partner-to-CAPN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by CAPN2-low versus CAPN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPN2→partner) and Y-score (partner→CAPN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.313	+2.887	<.001	<.001	3	2
UCEC	Akt_pS473 →	+0.509	+1.362	.044	.037	3	2
UCEC	p62 Lck ligand →	+0.284	+2.424	.013	.001	3	2
UCEC	PCNA →	+0.150	+1.807	.049	.025	3	2
UCEC	Rictor_pT1135 →	-0.085	-2.321	.019	.033	3	2
UCEC	STAT3_pY705 →	-0.326	-1.896	<.001	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Ku80 by CAPN2 expression — UCEC

Explore this box plot interactively →