CAPN2

Across TCGA pan-cancer cohorts, CAPN2 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated CAPN2 data layer compared with 6 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher CAPN2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CAPN2 expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

BLCA, PAAD, and LGG are the cancer types where CAPN2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.551	0.668	.004	69	view →
PAAD	OS	Median	All	0.295	0.507	.001	45	view →
LGG	DFS	Median	All	0.675	0.800	<.001	44	view →
ACC	DFS	Quartile	All	0.258	0.723	.004	39	view →
UVM	DFS	Median	III,IV	0.208	0.740	.006	35	view →
BRCA	OS	Median	IV	0.375	0.793	.004	35	view →
CESC	DFS	Tertile	All	0.391	0.706	<.001	34	view →
KIRC	DFS	Tertile	All	0.793	0.560	.008	30	view →
LUSC	OS	Tertile	All	0.695	0.803	.005	24	view →
MESO	DFS	Median	III,IV	0.210	0.626	.004	23	view →
UCS	OS	Tertile	IV	0.679	0.308	.024	18	view →
LUAD	DFS	Tertile	All	0.697	0.836	.013	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

CAPN2–BLCA (OS)

Open the BLCA breakdown →