CAPN2

Across TCGA cell cohorts, CAPN2 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,362 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CAPN2-associated GO terms across cancer lineages are Regulation of cell-substrate adhesion, Death-inducing signaling complex assembly, and Integrin-mediated signaling pathway. Each is linked with CAPN2 in more than 16 cancer types. Because this analysis shows association rather than direction, both CAPN2-to-partner and partner-to-CAPN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cell-substrate adhesion grouped by CAPN2-low versus CAPN2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPN2→partner) and Y-score (partner→CAPN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of cell-substrate adhesion →	+0.137	+1.508	<.001	<.001	3	17
LUNG_SCLC	Death-inducing signaling complex assembly →	+0.171	+1.253	.004	.001	3	16
BONE	Integrin-mediated signaling pathway →	+0.259	+1.616	<.001	<.001	3	16
BONE	Regulation of cell-matrix adhesion →	+0.163	+1.735	<.001	<.001	3	16
BONE	Membrane raft organization →	+0.197	+1.707	<.001	<.001	3	16
LIVER	Urokinase plasminogen activator signaling pathway →	+1.239	+2.709	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,362 associations by consensus.

Regulation of cell-substrate adhesion by CAPN2 expression — BONE

Explore this box plot interactively →