CAPN2

Across TCGA cell cohorts, CAPN2 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible CAPN2-associated genes across cancer lineages are PRAMEF33, GML, and GOLGA6L6. Each is linked with CAPN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAPN2-to-partner and partner-to-CAPN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF33 grouped by CAPN2-low versus CAPN2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPN2→partner) and Y-score (partner→CAPN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PRAMEF33 →	+0.023	+5.415	<.001	.004	3	2
OESOPHAGUS	GML →	+0.026	+4.906	<.001	.006	3	1
OESOPHAGUS	GOLGA6L6 →	+0.016	+4.906	<.001	.006	3	1
LARGE_INTESTINE	ASPN →	+0.035	+3.648	.004	.002	3	1
LARGE_INTESTINE	GRK7 →	+0.082	+3.374	.003	.005	3	1
SKIN	OR8B4 →	+0.035	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

PRAMEF33 by CAPN2 expression — SKIN

Explore this box plot interactively →