CAPN15

Across TCGA cell cohorts, CAPN15 mutation is significantly associated with the RNA expression of many other genes, with 455 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CAPN15-associated genes across cancer lineages are OR5H8, LECT2, and OR1C1. Each is linked with CAPN15 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAPN15-to-partner and partner-to-CAPN15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5H8 grouped by CAPN15-low versus CAPN15-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPN15→partner) and Y-score (partner→CAPN15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR5H8 →	+0.014	+4.247	<.001	<.001	3	2
CNS	LECT2 →	+0.426	+4.004	<.001	.002	3	2
CNS	OR1C1 →	+0.040	+3.700	<.001	.003	3	2
BLOOD_Leukemia	PDGFRL →	+1.002	+2.489	<.001	.007	3	2
BLOOD_Leukemia	ASIC1 →	+1.477	+3.674	.001	<.001	3	2
BLOOD_Leukemia	DOC2A →	+1.098	+2.489	.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 455 associations by consensus.

OR5H8 by CAPN15 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →