CAPN10

Across TCGA patient cohorts, CAPN10 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAPN10-associated genes across cancer lineages are JNK_pT183_Y185, Lck, and MSH2. Each is linked with CAPN10 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAPN10-to-partner and partner-to-CAPN10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by CAPN10-low versus CAPN10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPN10→partner) and Y-score (partner→CAPN10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.212	-1.893	.001	.016	3	2
UCEC	Lck →	+0.259	+2.584	.001	.010	3	2
UCEC	MSH2 →	-0.303	-3.295	.001	.009	3	2
UCEC	MSH6 →	-0.400	-2.321	.002	.033	3	2
UCEC	14-3-3_beta →	-0.136	-3.558	<.001	.002	3	1
UCEC	eEF2 →	+0.405	+3.321	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

JNK_pT183_Y185 by CAPN10 expression — UCEC

Explore this box plot interactively →