CAPN10

Across TCGA pan-cancer cohorts, CAPN10 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CAPN10’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CAPN10 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CAPN10 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

COAD, LIHC, and STAD are the cancer types where CAPN10 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CAPN10 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	IV	+1.184	<.001	11	view →
LIHC	Female	II,III,IV	+0.999	<.001	9	view →
STAD	Male	II,III,IV	+1.097	<.001	8	view →
BLCA	All	All	+0.489	.003	8	view →
UCEC	All	All	+0.529	<.001	6	view →
CHOL	Male	All	+2.346	<.001	5	view →
HNSC	Male	III,IV	+0.534	.007	5	view →
KICH	All	All	−0.409	.002	4	view →
READ	Female	All	+1.182	<.001	3	view →
KIRP	All	IV	+0.957	.035	2	view →
ESCA	All	All	+0.782	.007	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CAPN10–COAD

Open the COAD breakdown →