CAPN10

Across TCGA cell cohorts, CAPN10 mutation is significantly associated with the RNA expression of many other genes, with 334 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CAPN10-associated genes across cancer lineages are LRRC3C, OR4X2, and CCR8. Each is linked with CAPN10 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAPN10-to-partner and partner-to-CAPN10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC3C grouped by CAPN10-low versus CAPN10-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPN10→partner) and Y-score (partner→CAPN10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LRRC3C →	+0.199	+3.000	.002	<.001	3	2
SOFT_TISSUE	OR4X2 →	+0.024	+4.369	<.001	.008	3	1
SOFT_TISSUE	CCR8 →	+0.016	+4.369	<.001	.008	3	1
SOFT_TISSUE	BHLHA9 →	+0.027	+4.977	<.001	.002	3	1
SOFT_TISSUE	GOLGA6L6 →	+0.009	+4.369	<.001	.008	3	1
URINARY_TRACT	GADL1 →	+0.010	+4.050	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 334 associations by consensus.

LRRC3C by CAPN10 expression — LARGE_INTESTINE

Explore this box plot interactively →