CAPN10-DT

Across TCGA pan-cancer cohorts, CAPN10-DT RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated CAPN10-DT data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher CAPN10-DT RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CAPN10-DT expression acts as an unfavorable survival marker, although some lineages such as KICH and PAAD show a favorable association.

KIRC, ACC, and LIHC are the cancer types where CAPN10-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.500	0.714	<.001	123	view →
ACC	DFS	Median	All	0.368	0.799	<.001	115	view →
LIHC	DFS	Quartile	All	0.364	0.576	<.001	49	view →
KICH	OS	Median	All	0.974	0.855	.006	45	view →
UCEC	DFS	Median	All	0.580	0.709	<.001	42	view →
UVM	DFS	Tertile	III,IV	0.230	0.797	.002	38	view →
PAAD	DFS	Median	All	0.363	0.173	.003	30	view →
COAD	OS	Quartile	All	0.695	0.898	.002	27	view →
BLCA	OS	Quartile	All	0.791	0.634	.006	26	view →
PRAD	DFS	Tertile	All	0.809	0.948	<.001	26	view →
THYM	OS	Median	II,III,IV	0.952	0.725	.006	23	view →
LGG	DFS	Median	All	0.332	0.450	<.001	23	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

CAPN10-DT–KIRC (OS)

Open the KIRC breakdown →